Research
Hormonal
Testosterone administration increases muscle power and function, but its use is limited by potential side effects, particularly cardiovascular events and prostate malignancy risk, which vary by administration route.
Testosterone can improve muscle power and function, but it is not a first-line treatment due to potential side effects. If considered, the route of administration matters: oral testosterone may carry higher cardiovascular risks compared to transdermal or injection methods. Consult a physician to weigh benefits against risks.
GoodQualifiesHIGH confidence
Also, testosterone has been shown to increased muscle power and function; however, a possible limitation is the side effects of testosterone.
Why this rating
Supported by a meta-analysis of 35 RCTs mentioned in the text.
Source
Muscle Wasting and Sarcopenia in Heart Failure and Beyond: Update 2017
Jochen Springer et al. · ESC Heart Failure · 2017
DOI 10.1002/ehf2.12237
narrative_reviewCited 245×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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