Hormonal
In very old community-living men, higher baseline serum IGF-1 levels predict smaller losses in fat-free mass (FFM) over a 2-year period, suggesting anabolic protection against sarcopenia.
If you are an older man concerned about muscle loss, your natural hormone levels (specifically IGF-1) play a crucial role in preserving muscle mass. While you should still maintain physical activity and adequate protein, this research suggests that hormonal decline is a major driver of sarcopenia in this age group. Monitoring health markers and discussing hormonal health with a physician may be as important as lifestyle habits.
Higher IGF-1 predicted smaller loss of FFM in men than lower IGF-1 did (P <.002), after adjusting for age, baseline FFM, fat mass, and 2-year weight changes
Why this rating
Longitudinal cohort study with multivariate adjustment for confounders, though observational nature limits causal inference.
Source
Insulin‐Like Growth Factor‐1 and Interleukin 6 Predict Sarcopenia in Very Old Community‐Living Men and Women: The Framingham Heart Study
Hélène Payette et al. · Journal of the American Geriatrics Society · 2003
DOI 10.1046/j.1532-5415.2003.51407.x
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