Hormonal
Obstructive sleep apnoea syndrome (OSAS) is associated with abnormal lipid peroxidation, specifically higher levels of oxidized LDL and increased susceptibility to oxidation, which contributes to cardiovascular disease risk.
If you have severe sleep apnoea, your body is experiencing increased oxidative stress on your blood vessels, which raises your risk of heart disease. Using CPAP therapy for more than a year can significantly improve the susceptibility of your LDL to oxidation, potentially mitigating this risk. It is crucial to adhere to CPAP treatment to manage these metabolic effects.
These results indicate that obstructive sleep apnoea syndrome is associated with abnormal lipid peroxidation and that this is improved by chronic use of Continuous positive airway pressure. These results can contribute towards explaining the high prevalence of cardiovascular diseases seen in Obstructive sleep apnoea syndrome.
Why this rating
Small sample size (n=14 patients, n=13 controls) and lack of randomization limit the strength of conclusions.
Source
Abnormal lipid peroxidation in patients with sleep apnoea
Antònia Barceló et al. · European Respiratory Journal · 2000
DOI 10.1034/j.1399-3003.2000.16d13.x
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