Research
Hormonal
Low levels of adiponectin are associated with an increased risk of various cancers, including breast, liver, pancreatic, prostate, ovarian, and colorectal cancers.
Maintaining a healthy body weight helps preserve normal adiponectin levels, which may lower the risk of several obesity-associated cancers. This is one of many factors in cancer prevention.
GoodSupportsHIGH confidence
A plethora of experimental evidence supports the role of obesity and increased adiposity in multiple cancers including breast, liver, pancreatic, prostrate, ovarian, and colorectal cancers.
Why this rating
Supported by multiple experimental studies cited in the review.
Source
Adiponectin, Obesity, and Cancer: Clash of the Bigwigs in Health and Disease
Sheetal Parida et al. · International Journal of Molecular Sciences · 2019
DOI 10.3390/ijms20102519
narrative_reviewCited 242×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Thiazolidinediones (TZDs) increase circulating adiponectin levels, particularly the high molecular weight (HMW) form, by stimulating transcription and preventing ER retention.Good
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