Hormonal
Treatment with combined naltrexone-sustained release (32 mg) and bupropion-sustained release (360 mg) (NB32) attenuates hypothalamic brain reactivity to food cues while enhancing activation in regions responsible for self-control, memory, and interoception.
If you struggle with intense food cravings or lack of satiety signals, this medication (NB32) may help by reducing the brain's 'pull' towards food cues and enhancing your ability to use self-control and awareness of fullness. It is not a magic bullet but works by changing how your brain processes food signals. Consult a doctor to see if you are a candidate, as side effects can occur.
NB32 attenuated the activation in the hypothalamus in response to food cues (P<0.01), it enhanced activation in regions involved in inhibitory control (anterior cingulate), internal awareness (superior frontal, insula, superior parietal) and memory (hippocampal) regions (whole-brain analysis; P<0.05).
Why this rating
Randomized controlled trial with fMRI outcomes, though short duration (4 weeks) and small sample size (n=40).
Source
Effect of combined naltrexone and bupropion therapy on the brain’s reactivity to food cues
G-J Wang et al. · International Journal of Obesity · 2013
DOI 10.1038/ijo.2013.145
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →