Hormonal
Targeting the Ghrelin Receptor (GHSR1a) with inverse agonists or antagonists like LEAP2 reduces food intake and postprandial glucose, offering a potential treatment for type-2 diabetes and obesity.
A new approach to blocking hunger involves a natural peptide called LEAP2. In a small study, giving LEAP2 intravenously reduced how much people ate and lowered their blood sugar after meals. This suggests it might help people with type-2 diabetes or obesity, but more research is needed to see if these benefits last long-term.
a recent small clinical trial in 20 healthy individuals showed that intravenous administration of LEAP2 could successfully reduce food intake, meal duration and postprandial glucose, presenting the possibility that LEAP2 could be of clinical utility in type-2 diabetes and obesity
Why this rating
Based on a small clinical trial (n=20) and pre-clinical data; long-term effects and efficacy in diabetic/obese patients need further validation.
Source
RISING STARS: Targeting G protein-coupled receptors to regulate energy homeostasis
Aqfan Jamaluddin et al. · Journal of Molecular Endocrinology · 2023
DOI 10.1530/jme-23-0014
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