Hormonal
Combined oral administration of Scutellariae Radix and Coptidis Rhizoma extracts improves glucose and lipid metabolism in Type 2 Diabetes Mellitus (T2DM) models by downregulating the MAPK inflammatory pathway and upregulating the PI3K/Akt insulin signaling pathway.
This research suggests that a specific combination of Scutellariae Radix and Coptidis Rhizoma extracts may help regulate blood sugar and lipids in T2DM by reducing inflammation and improving insulin signaling. However, this is an animal study; human dosing, safety, and efficacy are not established here. Do not self-medicate with these herbs based on this paper alone.
Remarkably, hyperglycaemia, dyslipidemia, inflammation, and insulin resistance in T2DM were ameliorated after oral administration of SR and CR, particularly their combined extracts... the MAPK pathway might account for the phenomenon with down-regulation of MAPK... mRNA levels of key targets such as insulin receptor substrate 1 (IRS1), PI3K, Akt2, and Glut2 in the insulin signaling pathway were notably up-modulated
Why this rating
The study uses a valid T2DM rat model (HFD+STZ) with rigorous biochemical and molecular analysis, but results are pre-clinical.
Source
Scutellariae Radix and Coptidis Rhizoma Improve Glucose and Lipid Metabolism in T2DM Rats via Regulation of the Metabolic Profiling and MAPK/PI3K/Akt Signaling Pathway
Xiang Cui et al. · International Journal of Molecular Sciences · 2018
DOI 10.3390/ijms19113634
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →