Research
Hormonal
Forced activation of the MAPK/Notch pathway restores youthful myogenic responses in satellite cells from 70-year-old humans.
Research suggests that targeting the MAPK/Notch signaling pathway could potentially reactivate dormant muscle stem cells in the elderly, offering a potential therapeutic avenue for age-related muscle loss.
GoodSupportsHIGH confidence
activation of MAPK/Notch restored ‘youthful’ myogenic responses to satellite cells from 70-year-old humans, rendering them similar to cells from 20-year-old humans.
Why this rating
Strong mechanistic evidence in vitro, directly supporting the abstract's claim.
Source
Molecular aging and rejuvenation of human muscle stem cells
Morgan E. Carlson et al. · EMBO Molecular Medicine · 2009
DOI 10.1002/emmm.200900045
cohort · n=21Cited 241×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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