Research

Hormonal

Shifting the sleep/wake schedule relative to the endogenous circadian rhythm (as seen in shift work) increases the daily peak-to-trough fluctuation of circulating leptin, resulting in lower leptin levels upon awakening.

If you work shifts or have an irregular sleep schedule, your body's internal clock may be out of sync with your sleep times, causing your leptin (satiety hormone) to drop significantly when you wake up. This low leptin state can increase appetite and food intake. To mitigate this, try to align your sleep schedule as closely as possible with your natural circadian rhythm, or use bright light exposure upon waking to help reset your internal clock.

GoodSupportsHIGH confidence
Our data imply that alterations in the sleep/wake schedule would lead to an increased daily range in circulating leptin, with lowest leptin upon awakening, which, by influencing food intake and energy balance, could be implicated in the increased prevalence of obesity in the shift work population.
Steven A. Shea et al. · The Journal of Clinical Endocrinology & Metabolism · 2005

Why this rating

Controlled constant routine protocol in healthy humans, though small sample size (n=6).

Source

Independent Circadian and Sleep/Wake Regulation of Adipokines and Glucose in Humans

Steven A. Shea et al. · The Journal of Clinical Endocrinology & Metabolism · 2005

DOI 10.1210/jc.2004-2232

crossover · n=6Cited 241×
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DOI resolved against Crossref · corpus check 2026-06-10

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