Macro partitioning
A low-carbohydrate, ketogenic diet (<20 g carbohydrate/day) produces significantly greater weight loss and improves lipid profiles (lower triglycerides, higher HDL) compared to a low-fat, reduced-calorie diet over 24 weeks in overweight, hyperlipidemic adults.
If you are overweight and have high cholesterol, switching to a very low-carb diet (under 20g carbs/day) for 6 months will likely result in nearly double the weight loss compared to a standard low-fat diet, while significantly improving your triglyceride and HDL levels. You do not need to count calories strictly, but you must avoid grains, sugars, and most fruits initially. Expect some initial side effects like fatigue or constipation, which can be managed with water, salt, and supplements. Monitor your LDL cholesterol, as a minority of people may see it rise.
At 24 weeks, weight loss was greater in the low-carbohydrate diet group than in the low-fat diet group (mean change, -12.9% vs. -6.7%; P < 0.001)... recipients of the low-carbohydrate diet had greater decreases in serum triglyceride levels... and greater increases in high-density lipoprotein cholesterol levels...
Why this rating
Randomized controlled trial with 120 participants, but limited to 24 weeks and with confounding supplements in one arm.
Source
Low-fat versus Low-carbohydrate Diet
Dalal J. Alsharif · Journal of Nature and Science of Medicine · 2024
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