Research
Hormonal
Caloric restriction extends lifespan and improves insulin sensitivity in mice regardless of whether the Nrf2 pathway is functional.
Caloric restriction improves metabolic health and extends lifespan through mechanisms that do not rely on the Nrf2 stress-response pathway. This suggests that even if your Nrf2 system is compromised, you may still gain longevity and metabolic benefits from calorie restriction.
GoodSupportsHIGH confidence
However, CR extended lifespan and increased insulin sensitivity similarly in KO and WT mice.
Why this rating
Controlled animal study with clear genotype controls and statistical significance.
Source
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
Kevin J. Pearson et al. · Proceedings of the National Academy of Sciences · 2008
DOI 10.1073/pnas.0712162105
mechanism_onlyCited 238×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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