Research
Hormonal
Myostatin inhibition increases muscle mass but does not protect against age-related sarcopenia or force decline, and may even worsen force development in aging.
Do not rely on myostatin inhibitors for anti-aging. Focus on exercise, which naturally regulates myostatin and improves function without the side effects of genetic manipulation.
GoodRefutesHIGH confidence
However, other studies have indicated that the muscles in myostatin-null mice, though increased in mass, are not protected from sarcopenia... and with aging may even display a greater than expected decline in force development.
Why this rating
Based on multiple studies in myostatin-null mice.
Source
The influence of skeletal muscle on systemic aging and lifespan
Fabio Demontis et al. · Aging Cell · 2013
DOI 10.1111/acel.12126
narrative_reviewCited 237×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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