Research
Hormonal
SIRT1 upregulates orexin type 2 receptor (OX2R) expression in the hypothalamus, augmenting the response to ghrelin during diet restriction.
During diet restriction, your body increases ghrelin (hunger hormone). SIRT1 helps your brain respond to this by increasing orexin receptors, which drives activity and metabolism.
GoodSupportsHIGH confidence
SIRT1 upregulates expression of the orexin type 2 receptor specifically in these hypothalamic nuclei in response to diet-restricting conditions, augmenting response to ghrelin, a gut hormone whose levels increase in these conditions.
Why this rating
Supported by luciferase assays, ChIP, and in situ hybridization.
Source
SIRT1 Promotes the Central Adaptive Response to Diet Restriction through Activation of the Dorsomedial and Lateral Nuclei of the Hypothalamus
Akiko Satoh et al. · Journal of Neuroscience · 2010
DOI 10.1523/jneurosci.1385-10.2010
mechanism_onlyCited 237×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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