Research

Hormonal

Adopting a low glycemic index (GI) diet does not improve cardiovascular risk factors or insulin sensitivity compared to a high GI diet when total carbohydrate intake is high and other nutrients are controlled.

If you eat a high-carbohydrate diet, switching to 'low glycemic index' foods (like swapping white bread for whole wheat or pasta for lentils) will not necessarily improve your insulin sensitivity or heart health markers. In fact, this study suggests it might slightly worsen insulin sensitivity and raise LDL cholesterol compared to high GI carbs, provided your total calories, fiber, and saturated fat remain constant. Focus on reducing total carbohydrate quantity if you want to improve triglycerides and insulin sensitivity, rather than just swapping carb types.

StrongRefutesVERY_HIGH confidence
In this 5-week controlled feeding study, diets with low glycemic index of dietary carbohydrate, compared with high glycemic index of dietary carbohydrate, did not result in improvements in insulin sensitivity, lipid levels, or systolic blood pressure.
Frank M. Sacks et al. · JAMA · 2014

Why this rating

Randomized crossover-controlled feeding trial with high adherence (96% person-days), controlling for confounders like weight and macronutrients.

Source

Effects of High vs Low Glycemic Index of Dietary Carbohydrate on Cardiovascular Disease Risk Factors and Insulin Sensitivity

Frank M. Sacks et al. · JAMA · 2014

DOI 10.1001/jama.2014.16658

crossover · n=163Cited 235×
Read the paper
DOI resolved against Crossref · corpus check 2026-06-10

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