Research
Hormonal
Activation of the AMP-activated protein kinase (AMPK) pathway extends lifespan and stress resistance by directly phosphorylating and activating DAF-16/FOXO.
AMPK, an energy sensor, extends lifespan by directly activating the DAF-16/FOXO transcription factor. This mechanism links cellular energy status (low glucose/high AMP) to longevity pathways.
GoodSupportsHIGH confidence
DAF-16 is necessary for AMPK function in oxidative stress resistance and longevity... AMPK activates the DAF-16 transcription activity by phosphorylation as AMPK could directly phosphorylates DAF-16 in vitro.
Why this rating
Supported by specific studies on AMPK overexpression and DAF-16 dependency.
Source
DAF-16/FOXO Transcription Factor in Aging and Longevity
Xiaojuan Sun et al. · Frontiers in Pharmacology · 2017
DOI 10.3389/fphar.2017.00548
narrative_reviewCited 235×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Inhibition of the Insulin/IGF-1 signaling (IIS) pathway extends lifespan by promoting the nuclear translocation of the DAF-16/FOXO transcription factor, which then activates downstream genes for stress resistance and longevity.Good
- Dietary restriction (caloric or nutrient restriction) extends lifespan by inactivating the TOR (Target of Rapamycin) pathway, which subsequently influences DAF-16/FOXO activity and mRNA levels.Good
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