Hormonal
Central administration of GLP-1 receptor agonists (GLP-1(7-36) amide or exendin-4) inhibits food and water intake in rats via hypothalamic glucose-sensing mechanisms, whereas peripheral administration has no acute effect on intake.
Central GLP-1 signaling strongly suppresses food and water intake in rats, while peripheral signaling does not. This suggests that for appetite suppression, the route of delivery and central receptor engagement are critical.
These findings suggest that GLP-1 (7—36) amide may modulate both food and drink intake in the rat through a central mechanism.
Why this rating
High-quality in vivo animal study with dose-response and antagonist reversal.
Source
Colocalization of Glucagon‐Like Peptide‐1 (GLP‐1) Receptors, Glucose Transporter GLUT‐2, and Glucokinase mRNAs in Rat Hypothalamic Cells: Evidence for a Role of GLP‐1 Receptor Agonists as an Inhibitory Signal for Food and Water Intake
Miguel Navarro et al. · Journal of Neurochemistry · 1996
DOI 10.1046/j.1471-4159.1996.67051982.x
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