Research
Hormonal
Rapamycin exhibits sexual dimorphism in efficacy, extending lifespan significantly more in female mice than in male mice.
If rapamycin is used for longevity, women may derive greater lifespan benefits than men, potentially due to differences in drug metabolism or baseline mTOR signaling. Men may require careful monitoring for side effects like insulin resistance.
GoodQualifiesHIGH confidence
Consistently, rapamycin has shown to benefit females more than males, in both UM-HET3 genetically heterogeneous mice and inbred C57BL/6J mice, and independent of starting treatment when young or old (Table 1).
Why this rating
Consistent across multiple mouse strains and studies.
Source
Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island
Sebastian I. Arriola Apelo et al. · The Journals of Gerontology Series A · 2016
DOI 10.1093/gerona/glw090
narrative_reviewCited 233×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Chronic inhibition of mTORC2 by rapamycin causes metabolic dysfunction (glucose intolerance, insulin resistance) and immunosuppression, acting as the primary barrier to its use as an anti-aging therapy.Strong
- Intermittent administration of rapamycin (e.g., 2 mg/kg every 5 days) extends lifespan in mice while minimizing metabolic and immunological side effects associated with chronic dosing.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →