Hormonal
Combining metformin (2,000 mg/day) with exercise training does not enhance whole-body insulin sensitivity in individuals with prediabetes compared to exercise training alone, and may blunt the full effect of exercise.
If you have prediabetes, exercise training significantly improves your insulin sensitivity. Adding metformin does not provide extra benefit for insulin sensitivity and might actually reduce the gains you get from exercise. Focus on consistent exercise (aerobic and resistance) as the primary driver for improving insulin sensitivity, and discuss with your doctor whether metformin is necessary for other reasons (like weight loss or diabetes prevention) rather than expecting it to boost exercise benefits.
Contrary to our original hypothesis, adding metformin did not accentuate the effects of exercise training on whole-body insulin sensitivity in this group of men and women with prediabetes. Consistent with our prior study of acute exercise, the addition of metformin may have blunted the response to exercise training alone.
Why this rating
Randomized controlled trial with gold-standard measurement (euglycemic hyperinsulinemic clamp), but small sample size (n=8 per group).
Source
Independent and Combined Effects of Exercise Training and Metformin on Insulin Sensitivity in Individuals With Prediabetes
Steven K. Malin et al. · Diabetes Care · 2011
DOI 10.2337/dc11-0925
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