Hormonal
Type 2 diabetes acts as an independent risk factor that accelerates the progression of nonalcoholic fatty liver disease (NAFLD) to advanced fibrosis and cirrhosis, and conversely, NAFLD predicts the development of type 2 diabetes.
If you have Type 2 Diabetes or Prediabetes, your liver health is inextricably linked to your blood sugar control. Managing your glucose and insulin levels is not just about preventing complications elsewhere; it is a primary strategy to stop fatty liver from progressing to serious scarring (fibrosis). Conversely, treating liver inflammation may help stabilize your diabetes risk. Regular screening for liver fibrosis is critical for this population.
NAFLD predicts the development of type 2 diabetes and vice versa, and each condition may serve as a progression factor for the other... diabetes appears to accelerate the progression of NAFLD to nonalcoholic steatohepatitis, defined by the presence of necroinflammation, with varying degrees of liver fibrosis.
Why this rating
Based on a comprehensive review of epidemiological evidence, human studies, and animal models, though it is a review paper rather than a single RCT.
Source
Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo
Kathryn Williams et al. · Endocrine Reviews · 2012
DOI 10.1210/er.2012-1009
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