Hormonal
Pharmacological inhibition of hypothalamic Sirt1 reduces food intake and alters melanocortin system synaptic connectivity by decreasing Agrp neuron activity.
This research identifies a specific brain pathway where inhibiting the enzyme Sirt1 reduces food intake in mice. It does not currently translate to a human supplement or drug recommendation, as the effects are specific to hypothalamic neurons and involve complex neural circuitry. Caution is advised against interpreting 'Sirt1 inhibition' as a general weight-loss strategy without understanding the specific neural context.
In adult mice, the pharmacological inhibition of brain Sirt1 activity decreased Agrp neuronal activity and the inhibitory tone on the anorexigenic POMC neurons... When a Sirt1 inhibitor (EX-527) was injected either peripherally (i.p., 10 mg/kg) or directly into the brain (i.c.v., 1.5 nmol/mouse), it decreased both food intake during the dark cycle and ghrelin-induced food intake.
Why this rating
Strong experimental evidence using multiple models (pharmacological inhibition, genetic knockout) in mice, though translational to humans is not explicitly claimed.
Source
Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity
Marcelo O. Dietrich et al. · Journal of Neuroscience · 2010
DOI 10.1523/jneurosci.2234-10.2010
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