Research
Hormonal
Calorie restriction extends lifespan in yeast by acting as a mild biological stressor that activates the Sir2 deacetylase, rather than by simply slowing metabolism or reducing oxidative damage.
Calorie restriction extends lifespan in yeast by activating Sir2 through a mild stress response. This suggests that mild, intermittent reductions in caloric intake may trigger similar survival pathways in humans, potentially delaying age-related diseases.
GoodSupportsHIGH confidence
Recent findings in the yeast Saccharomyces cerevisiae indicate that CR extends lifespan because it is a mild biological stressor that activates Sir2, a key component of yeast longevity and the founding member of the sirtuin family of deacetylases.
Why this rating
The paper reviews multiple lines of evidence in yeast, including genetic manipulations and enzyme activity studies, establishing a strong mechanistic link.
Source
MicroReview: Small molecules that regulate lifespan: evidence for xenohormesis
Dudley W. Lamming et al. · Molecular Microbiology · 2004
DOI 10.1111/j.1365-2958.2004.04209.x
narrative_reviewCited 231×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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