Hormonal
Probiotic administration in early life, likely via the production of short-chain fatty acids (SCFAs) like butyrate, can restore gut microbiota balance and exert epigenetic effects (HDAC inhibition) that prevent chronic immune-mediated diseases.
If considering probiotics for an infant (especially after C-section or antibiotic use), consult a pediatrician. The goal is to support a healthy gut microbiota early in life, which may help program a robust immune system and reduce the risk of allergies via epigenetic mechanisms like butyrate production.
In this regard probiotics, which have the potential to restore the intestinal microbiota balance, may be effective in preventing the development of chronic immune-mediated diseases. ... the epigenetic mechanisms elicited by probiotics through the production of SCFA are hypothesised to be the key to understand how they mediate their numerous health-promoting effects from the gut to the peripheral tissues.
Why this rating
The paper states the mechanism is 'hypothesised' and notes that exact mechanisms are 'yet to be fully understood', relying on animal models and theoretical frameworks.
Source
Epigenetic mechanisms elicited by nutrition in early life
Roberto Berni Canani et al. · Nutrition Research Reviews · 2011
DOI 10.1017/s0954422411000102
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →