Hormonal
Increased body adiposity, specifically higher BMI and adult weight gain, significantly increases the risk of breast cancer in postmenopausal women, particularly for hormone receptor-positive (HR+) tumors.
Maintain a healthy body weight and avoid adult weight gain to reduce breast cancer risk after menopause. This is especially important for preventing hormone receptor-positive breast cancers.
adult weight gain and greater body adiposity increased breast cancer risk in postmenopausal women, and the increased risk was evident for HR+ but not HR− breast cancers
Why this rating
Large meta-analysis of 75 studies for BMI and 16 for weight gain in postmenopausal women; consistent positive associations observed.
Source
World Cancer Research Fund International: Continuous Update Project—systematic literature review and meta-analysis of observational cohort studies on physical activity, sedentary behavior, adiposity, and weight change and breast cancer risk
Doris S.M. Chan et al. · Cancer Causes & Control · 2019
DOI 10.1007/s10552-019-01223-w
More from this paper
- Higher levels of physical activity, particularly vigorous intensity, are inversely associated with the risk of developing breast cancer in both premenopausal and postmenopausal women.Good
- Higher early adult BMI (ages 18-30) is inversely associated with breast cancer risk in both pre- and postmenopausal women, suggesting a protective effect of higher adiposity during young adulthood.Good
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