Research
Adherence
Regular exercise reduces oxidatively modified proteins in the brain and improves cognitive function through PTM processes involving histone regulation.
Regular physical activity helps protect the brain from age-related damage. It works by reducing oxidized proteins and improving how genes are regulated in the brain (via histone PTMs). This leads to better cognitive function as you age. Incorporating consistent movement into your routine is a key strategy for maintaining brain health.
ModerateSupportsMEDIUM confidence
Likewise, regular exercise has been found to reduce oxidatively modified proteins in the brain with improved cognitive functions [121], through processes involving PTMs in histone tails controlled by HATs, HDACs, and histone demethylases [122].
Why this rating
Cited as a finding from other studies ([121], [122]) within a review.
Source
Protein Posttranslational Modifications: Roles in Aging and Age‐Related Disease
Ana L. Santos et al. · Oxidative Medicine and Cellular Longevity · 2017
DOI 10.1155/2017/5716409
narrative_reviewCited 230×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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