Hormonal
Aberrant protein posttranslational modifications (PTMs) are central drivers of metabolic diseases including diabetes, obesity, and atherosclerosis, and targeting these modifications offers a viable therapeutic strategy.
Metabolic diseases are driven by complex molecular switches (PTMs) that regulate how your body processes energy. While lifestyle changes are the first line of defense, pharmaceutical interventions targeting these specific molecular pathways (like kinase inhibitors) are increasingly available and effective for managing conditions like diabetes and fatty liver disease when lifestyle changes are insufficient.
Aberrant PTMs are implicated in diverse human diseases, including metabolic disorders and CVDs. ... Drugs targeting PTMs have thus provided potential therapeutic strategies in the study of diverse diseases, including metabolic disorders.
Why this rating
This is a review article summarizing preclinical and clinical evidence; it is not a primary clinical trial itself.
Source
Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
Xiumei Wu et al. · Signal Transduction and Targeted Therapy · 2023
DOI 10.1038/s41392-023-01439-y
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