Hormonal
In women with polycystic ovarian syndrome (PCOS), abdominal obesity significantly worsens insulin resistance, whereas lean PCOS subjects exhibit only a non-significant trend toward impaired sensitivity.
If you have PCOS, your risk for insulin resistance is higher than average, but carrying excess abdominal weight makes it significantly worse. Lean women with PCOS may have mild issues, but obese women with PCOS face substantial metabolic impairment. Prioritizing the reduction of abdominal fat is a critical lever for improving insulin sensitivity in this population.
These results confirm and strengthen earlier contentions, that insulin resistance is a characteristic defect in PCOS and is worsened particularly by abdominal obesity.
Why this rating
The study uses the gold-standard euglycaemic hyperinsulinaemic clamp technique and includes a substantial sample size (n=77) with clear control groups.
Source
Insulin sensitivity, insulin secretion, and metabolic and hormonal parameters in healthy women and women with polycystic ovarian syndrome
Laure Morin‐Papunen et al. · Human Reproduction · 2000
DOI 10.1093/humrep/15.6.1266
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