Hormonal
Severe sedentary behavior increases the risk of sleep disturbance, and this association is significantly mediated by elevated blood-cell-based inflammatory biomarkers (WBC, NEU, NLR, SII).
If you sit for more than 480 minutes a day (severe sedentary behavior), your risk of sleep disturbance increases. This risk is partly driven by your body's inflammatory response (measurable by blood tests). To mitigate this, you must break up long periods of sitting with movement, as this reduces the inflammatory burden that disrupts sleep.
Mediation analysis showed that WBC, NEU, NLR, and SII mediated the statistical association between sedentary behavior and sleep disturbance with proportions (%) of 2.09, 2.27, 1.76, and 0.82, respectively.
Why this rating
Large population-based cross-sectional study (n=22,599) with rigorous statistical adjustment, though causality is limited by cross-sectional design.
Source
The association between sedentary behavior, exercise, and sleep disturbance: A mediation analysis of inflammatory biomarkers
Yanwei You et al. · Frontiers in Immunology · 2023
DOI 10.3389/fimmu.2022.1080782
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