Research
Hormonal
Longer duration of marine-derived n-3 PUFAs supplementation leads to a greater lowering effect on IL-6 and TNF-α in subjects with chronic non-autoimmune disease.
To get the most anti-inflammatory benefit from fish oil, you need to take it consistently for a long time. The reduction in inflammatory markers like IL-6 and TNF-α increases the longer you supplement, suggesting a commitment of several months is necessary.
GoodSupportsHIGH confidence
A significant negative linear relationship between duration and effect size of marine-derived n-3 PUFAs supplementation on fasting blood levels of TNF-a and IL-6 in subjects with chronic non-autoimmune disease was observed, indicating that longer duration of supplementation could lead to a greater lowering effect.
Why this rating
Meta-regression analysis within the meta-analysis.
Source
Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on C-Reactive Protein, Interleukin 6 and Tumor Necrosis Factor α: A Meta-Analysis
Kelei Li et al. · PLoS ONE · 2014
DOI 10.1371/journal.pone.0088103
Meta-analysis · 68 studiesCited 226×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Marine-derived n-3 polyunsaturated fatty acid (PUFA) supplementation significantly lowers fasting blood levels of C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) in subjects with chronic non-autoimmune disease, chronic autoimmune disease, and healthy subjects.Good
- The anti-inflammatory effect of marine-derived n-3 PUFAs on CRP is significantly weakened or absent in subjects with a BMI greater than 30 kg/m2.Good
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