Hormonal
Omega-3 polyunsaturated fatty acids (PUFA) counteract insulin resistance by modulating mitochondrial bioenergetics and reducing endoplasmic reticulum (ER) stress.
Omega-3s may help improve cellular metabolism and reduce stress in tissues like the liver and muscle, potentially supporting insulin sensitivity. However, human studies are inconsistent, so they should be viewed as a supportive part of a broader metabolic health strategy, not a standalone cure for insulin resistance.
Dietary omega 3 polyunsaturated fatty acids (PUFA) have been suggested to counteract insulin resistance development by modulating mitochondrial bioenergetics and ER stress.
Why this rating
The paper is a review summarizing animal/cell studies and noting conflicting human data; it is not a primary clinical trial.
Source
Omega-3 Fatty Acids and Insulin Resistance: Focus on the Regulation of Mitochondria and Endoplasmic Reticulum Stress
Marilena Lepretti et al. · Nutrients · 2018
DOI 10.3390/nu10030350
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