Hormonal
Semaglutide (1.0 mg once-weekly) significantly improves fasting and postprandial glucose and lipid metabolism in subjects with obesity, primarily through delayed first-hour gastric emptying and GLP-1 receptor agonism.
For individuals with obesity, semaglutide (1.0 mg weekly) significantly improves how the body handles glucose and fats after eating. This is achieved by slowing down the initial emptying of the stomach, which prevents rapid spikes in blood sugar and lipids. This benefit occurs even in people without diabetes, suggesting it may be a valuable tool for metabolic health in obesity.
Semaglutide improved fasting and postprandial glucose and lipid metabolism. Overall gastric emptying was similar to that with placebo; however, the observed first-hour delay with semaglutide may contribute to a slower entry of glucose into the circulation.
Why this rating
Randomized, double-blind, placebo-controlled, crossover trial with statistical significance reported for key endpoints.
Source
Semaglutide improves postprandial glucose and lipid metabolism, and delays first‐hour gastric emptying in subjects with obesity
Julie Hjerpsted et al. · Diabetes Obesity and Metabolism · 2017
DOI 10.1111/dom.13120
Related findings · Hormonal
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