Research
Hormonal
Sleep irregularity is associated with increased perceived stress and depressive symptoms, which may serve as additional mechanisms linking irregular sleep to cardiometabolic disease.
Recognize that mental health and sleep consistency are linked. If you are experiencing high stress or depressive symptoms, improving your sleep regularity (consistent bed/wake times) may help alleviate these symptoms and reduce your long-term risk of cardiovascular disease.
GoodSupportsHIGH confidence
Greater sleep irregularity was further correlated with increased depression severity and perceived stress, aspects of psychiatric health known to have bidirectional relationships with cardiometabolic disease.
Why this rating
Large sample, significant correlations, but cross-sectional design limits causal inference regarding stress/depression.
Source
Validation of the Sleep Regularity Index in Older Adults and Associations with Cardiometabolic Risk
Jessica R. Lunsford‐Avery et al. · Scientific Reports · 2018
DOI 10.1038/s41598-018-32402-5
cohort · n=1978Cited 223×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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