Hormonal
Physiologic testosterone replacement (300 mcg/day transdermal patch) significantly increases bone mineral density at the hip and radius, fat-free mass, and thigh muscle cross-sectional area in women with hypopituitarism-induced androgen deficiency.
For women with hypopituitarism and low testosterone, a physiologic dose of transdermal testosterone (300 mcg/day) improves bone density at the hip and radius, increases muscle mass, and improves mood and sexual function without increasing body fat. This treatment is well-tolerated, though mild skin irritation is common. It does not significantly improve spine bone density.
Mean free testosterone increased into the normal range during testosterone administration. Mean hip (P < 0.023) and radius (P < 0.007), but not posteroanterior spine, bone mineral density increased in the group receiving testosterone, compared with placebo, as did mean fat-free mass (P < 0.040) and thigh muscle area (P < 0.038), but there was no change in fat mass.
Why this rating
Randomized, double-blind, placebo-controlled design with statistically significant p-values for primary outcomes.
Source
Effects of Testosterone Replacement in Androgen-Deficient Women with Hypopituitarism: A Randomized, Double-Blind, Placebo-Controlled Study
Karen K. Miller et al. · The Journal of Clinical Endocrinology & Metabolism · 2006
DOI 10.1210/jc.2005-2596
More from this paper
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →