Hormonal
Skeletal muscle releases alpha-sarcoglycan-positive extracellular vesicles (EVs) containing muscle-specific microRNAs (myomiRs) into the bloodstream, serving as a mechanism for inter-organ communication and adaptation to exercise.
This research highlights that aerobic exercise triggers your muscles to release specific signaling molecules (miRNAs) packaged in protective vesicles. These signals likely help regulate muscle health and adaptation. To leverage this, prioritize consistent aerobic exercise (e.g., running, cycling) which has been shown to modulate these specific muscle-derived signals, rather than assuming all exercise types produce identical molecular benefits.
Thus, our study proposes EVs as a novel means of muscle communication potentially involved in muscle remodeling and homeostasis.
Why this rating
Small sample size (n=18-22), cross-sectional and acute bout design, no long-term clinical outcomes.
Source
Muscle Releases Alpha-Sarcoglycan Positive Extracellular Vesicles Carrying miRNAs in the Bloodstream
Michele Guescini et al. · PLoS ONE · 2015
DOI 10.1371/journal.pone.0125094
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