Hormonal
Irisin, a myokine released from skeletal muscle during exercise, directly enhances osteoblast differentiation and bone formation markers (ALP and Collagen I) in vitro.
While this study is in mice and cells, it suggests that the benefits of exercise for bone health are partly due to chemical signals (Irisin) released by your muscles, not just the physical stress on your bones. This supports the importance of regular physical activity for maintaining bone density, especially as you age.
Our results show, for the first time, that Irisin directly targets osteoblasts, enhancing their differentiation.
Why this rating
The study is an in vitro mechanism paper using mouse models; it establishes biological plausibility but lacks human clinical outcomes.
Source
Irisin Enhances Osteoblast Differentiation<i>In Vitro</i>
Graziana Colaianni et al. · International Journal of Endocrinology · 2014
DOI 10.1155/2014/902186
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