Hormonal
Daily oral administration of live Dysosmobacter welbionis J115T (1.0×10^9 CFU) prevents diet-induced obesity, reduces fat mass gain, and improves glucose tolerance in mice fed a high-fat diet.
In a mouse model, daily consumption of live Dysosmobacter welbionis J115T at a dose of 1 billion colony-forming units prevented weight gain and improved metabolic health during a high-fat diet. This effect was specific to live bacteria, as pasteurized versions were ineffective. This suggests that maintaining bacterial viability is critical for this specific strain's metabolic benefits.
gavaging high-fat diet (HFD)- fed mice with daily and freshly prepared live D. welbionis J115T (1.0×109 cultivable, live bacteria per day and per mouse) for 6 weeks (HFD J115- fresh group) decreased the HFD- induced weight gain by 29% (ie, 1.5 grams)
Why this rating
Strong preclinical evidence in mice with clear mechanistic pathways, but lacks human clinical trial data.
Source
<i>Dysosmobacter welbionis</i> is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice
Tiphaine Le Roy et al. · Gut · 2021
DOI 10.1136/gutjnl-2020-323778
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