Research
Hormonal
Adiposity causes coronary heart disease (CHD), although the causal effect size is smaller and less statistically robust than for heart failure or stroke in this specific analysis.
Managing your weight can help reduce your risk of coronary heart disease. While the link might be less direct than for heart failure, reducing adiposity can lower the risk of atherosclerosis and related heart issues. Consult with a healthcare provider for personalized advice.
ModerateQualifiesMEDIUM confidence
Additional cross-sectional analyses using both ENGAGE and CARDIoGRAMplusC4D data showed a causal effect of adiposity on CHD... The IV estimate supported a causal association between BMI and prevalent CHD [odds ratio (OR) = 1.47, 95% CI, 1.04–2.07, P = 0.03].
Why this rating
Causal link supported by cross-sectional data and larger consortia, but incident data showed no significant causal effect.
Source
Adiposity as a cause of cardiovascular disease: a Mendelian randomization study
Sara Hägg et al. · International Journal of Epidemiology · 2015
DOI 10.1093/ije/dyv094
Meta-analysis · 9 studiesCited 151×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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