Research
Hormonal
Melatonin supplementation is effective in preventing or reducing jet lag symptoms without meaningful side effects.
If you are traveling across multiple time zones, consider using melatonin supplements to help reduce jet lag symptoms. It is widely used and has no known meaningful side effects.
GoodSupportsHIGH confidence
In addition, melatonin is effective in preventing or reducing jet lag [99–103], and there is no evidence of any meaningful side effects.
Why this rating
Cited as effective with no meaningful side effects, based on multiple references.
Source
Protecting the Melatonin Rhythm through Circadian Healthy Light Exposure
María‐Ángeles Bonmatí‐Carrión et al. · International Journal of Molecular Sciences · 2014
DOI 10.3390/ijms151223448
narrative_reviewCited 219×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Nocturnal exposure to blue light (specifically ~460–480 nm) suppresses melatonin secretion and disrupts the circadian rhythm, increasing health risks such as metabolic syndrome and cancer.Good
- Daytime exposure to bright light, particularly blue wavelengths, is beneficial for circadian entrainment and health, whereas nighttime exposure is disruptive.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →