Hormonal
Intermuscular adipose tissue (iMAT) in elderly men is primarily driven by total body fat mass and age, with subclinical local inflammation (IL-6 expression) contributing to its presence.
For older men, managing total body fat is the most effective way to reduce fat infiltration in muscles. While inflammation plays a role, it is local tissue inflammation that matters most, not necessarily what shows up in standard blood tests. Focus on maintaining a healthy weight and addressing age-related changes.
iMAT was primarily related to age and total body adiposity; subclinical inflammation in fat significantly contributes to iMAT.
Why this rating
Small sample size (n=20) and cross-sectional design limit causal inference, though statistical associations are strong.
Source
Adipose Tissue Infiltration in Skeletal Muscle of Healthy Elderly Men: Relationships With Body Composition, Insulin Resistance, and Inflammation at the Systemic and Tissue Level
Elena Zoico et al. · The Journals of Gerontology Series A · 2009
DOI 10.1093/gerona/glp155
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