Hormonal
In obese patients with Alcohol Use Disorder (BMI > 30 kg/m2), exenatide significantly reduces heavy drinking days and total alcohol intake.
If you have Alcohol Use Disorder and are obese (BMI > 30), weekly exenatide injections may significantly reduce your heavy drinking days and total alcohol intake. This benefit was not seen in non-obese patients in this study, suggesting that metabolic health is a key factor in the drug's efficacy for addiction.
Exploratory analyses revealed that exenatide significantly reduced heavy drinking days and total alcohol intake in a subgroup of obese patients (BMI > 30 kg/m2).
Why this rating
Exploratory subgroup analysis, not pre-specified primary endpoint, though statistically significant.
Source
Exenatide once weekly for alcohol use disorder investigated in a randomized, placebo-controlled clinical trial
Mette Kruse Klausen et al. · JCI Insight · 2022
DOI 10.1172/jci.insight.159863
More from this paper
- Exenatide (2 mg once weekly) significantly reduces alcohol cue reactivity in the ventral striatum and septal area in patients with Alcohol Use Disorder, but does not significantly reduce heavy drinking days in the general AUD population.Good
- Exenatide treatment significantly reduces dopamine transporter (DAT) availability in the striatum, caudate, and putamen in patients with Alcohol Use Disorder.Good
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