Research
Hormonal
In the hypothalamus, nutrient sensing (specifically via malonyl-CoA and LCFA-CoA) triggers counterregulatory responses that decrease food intake and hepatic glucose production, acting as a negative feedback loop to peripheral insulin resistance.
Maintaining healthy levels of circulating nutrients helps preserve the brain's ability to sense energy status and regulate appetite. Chronic overfeeding can lead to central resistance, where the brain stops receiving the 'stop eating' signal.
ModerateSupportsHIGH confidence
In the hypothalamus, increased levels of malonyl-CoA and/or LCFA-CoA trigger counterregulatory responses that decrease food intake and endogenous glucose production.
Why this rating
Based on minireview synthesis of central administration studies.
Source
Minireview: Nutrient Sensing and the Regulation of Insulin Action and Energy Balance
Silvana Obici et al. · Endocrinology · 2003
DOI 10.1210/en.2003-0999
narrative_reviewCited 214×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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