Research
Hormonal
Nonalcoholic fatty liver disease (NAFLD) is an independent predictor of incident cardiovascular events, driven by hepatic insulin resistance and systemic inflammation.
Fatty liver is not just a liver problem; it significantly increases your risk of heart disease and stroke, independent of your weight. Managing liver fat is crucial for cardiovascular health.
GoodSupportsHIGH confidence
Nonalcoholic fatty liver disease has been found to be an independent predictor of incident cardiovascular events in patients with type 2 diabetes mellitus as well as normal subjects.
Why this rating
Supported by Framingham Heart Study and other cohort studies.
Source
Links Between Ectopic Fat and Vascular Disease in Humans
Soo Lim et al. · Arteriosclerosis Thrombosis and Vascular Biology · 2014
DOI 10.1161/atvbaha.114.303035
narrative_reviewCited 214×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Ectopic fat accumulation in visceral, hepatic, and pericardial depots acts as an active endocrine organ that promotes cardiovascular disease through insulin resistance, systemic inflammation, and oxidative stress, independent of overall body mass index.Good
- Visceral adipose tissue (VAT) volume is independently associated with cardiovascular events and subclinical atherosclerosis, mediated by increased lipolytic activity, low-grade inflammation, and oxidative stress.Good
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