Hormonal
NOX2-derived cytosolic ROS production is required for exercise-stimulated glucose uptake and GLUT4 translocation in skeletal muscle.
During moderate-intensity exercise, your body produces specific reactive oxygen species (ROS) via the NOX2 enzyme to signal muscles to take up glucose. This is a necessary signaling event, not just damage. While you don't need to 'increase' ROS intentionally, understanding that some oxidative stress is functional helps explain why extreme antioxidant supplementation might interfere with metabolic adaptations to exercise.
These findings indicate that NOX2 is a major myocellular ROS source, regulating glucose transport capacity during moderate-intensity exercise.
Why this rating
High-quality mechanistic evidence using multiple loss-of-function mouse models and human biopsies, though not a direct clinical intervention trial.
Source
Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise
Carlos Henríquez‐Olguín et al. · Nature Communications · 2019
DOI 10.1038/s41467-019-12523-9
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