Hormonal
Long non-coding RNAs (lncRNAs) regulate metabolic homeostasis, including glucose and energy balance, through mechanisms such as epigenetic modification, mRNA decay, and competing endogenous RNA (ceRNA) networks.
This paper highlights that non-coding RNAs play a crucial role in how your body manages energy and glucose. While there is no direct 'dosage' or intervention for a layperson, understanding this mechanism suggests that future therapies might target these RNA pathways to treat metabolic diseases like obesity and type 2 diabetes. For now, maintaining metabolic health through standard lifestyle interventions (diet and exercise) remains the primary strategy, as these may influence the expression of these regulatory RNAs.
We review those lncRNAs that are implicated in differentiation and homeostasis of metabolic tissues and present novel concepts on how lncRNAs might act on energy and glucose homeostasis.
Why this rating
The paper is a review of various studies, including in vitro and animal models, but notes that in vivo significance for many lncRNAs is still being elucidated.
Source
Regulation of metabolism by long, non-coding RNAs
Jan‐Wilhelm Kornfeld et al. · Frontiers in Genetics · 2014
DOI 10.3389/fgene.2014.00057
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