Hormonal
Liraglutide, a GLP-1 receptor agonist, improves glycemic control and reduces body weight in type 2 diabetes through glucose-dependent insulin secretion, glucagon suppression, and delayed gastric emptying, with a low risk of hypoglycemia.
Liraglutide is a once-daily injection for type 2 diabetes that helps control blood sugar and promotes weight loss. It works by mimicking a natural hormone (GLP-1) to increase insulin when blood sugar is high and decrease glucagon. Because it only works when blood sugar is elevated, it has a low risk of causing dangerously low blood sugar. Treatment starts at a lower dose to minimize stomach issues, then increases based on how well it controls your blood sugar.
The beneficial pharmacodynamic actions of liraglutide, including improved fasting and postprandial glycaemic control (mediated by increased insulin and reduced glucagon levels and minor delays in gastric emptying), reduced appetite and energy intake, and effects on postprandial lipid profiles.
Why this rating
Based on a comprehensive review of multiple phase III trials and pharmacokinetic/pharmacodynamic studies.
Source
Liraglutide in Type 2 Diabetes Mellitus: Clinical Pharmacokinetics and Pharmacodynamics
Lisbeth V. Jacobsen et al. · Clinical Pharmacokinetics · 2015
DOI 10.1007/s40262-015-0343-6
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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