Hormonal
Cold exposure activates the beta-3 adrenergic receptor system, leading to UCP1 upregulation and non-shivering thermogenesis, although human response varies significantly compared to rodents.
Cold exposure can activate brown fat via the beta-3 adrenergic system, but human response is highly variable and often weaker than in mice. While you can try cold showers or lower temperatures, do not rely on it as a primary weight loss strategy. Diet and exercise are more reliable and practical methods to increase metabolic rate.
β-3 adrenergic receptor system is one important mediator of white adipose tissue browning, during cold exposure.
Why this rating
Review paper; human studies show variable response.
Source
Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases
Sabrina Azevedo Machado et al. · Nutrition & Metabolism · 2022
DOI 10.1186/s12986-022-00694-0
More from this paper
- Dietary interventions including capsaicin, n-3 polyunsaturated fatty acids, and intermittent fasting promote white adipose tissue browning and metabolic efficiency, whereas a Western diet inhibits this process.Moderate
- Physical exercise induces white adipose tissue browning through the secretion of myokines such as Irisin, FGF21, and Beta-Aminoisobutyric acid, which upregulate UCP1 and thermogenic genes.Moderate
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