Hormonal
Shorter sleep duration (measured objectively via actigraphy) is associated with a lower secondary antibody response to the hepatitis B vaccine and a decreased likelihood of achieving clinical protection (anti-HBs IgG ≥ 10 mIU/ml).
If you are getting a vaccine, prioritize getting enough total hours of sleep in the days leading up to and following the shot. Objective sleep duration matters more for your immune response than how efficiently you sleep or how good you feel you slept. Aim for longer sleep duration (e.g., >7 hours) to maximize your antibody protection.
Regression analyses revealed that shorter actigraphy-based sleep duration was associated with a lower secondary antibody response independent of age, sex, body mass index, and response to the initial immunization. Shorter sleep duration, measured by actigraphy and sleep diary, also predicted a decreased likelihood of being clinically protected from hepatitis B at the conclusion of the vaccination series.
Why this rating
Prospective observational study with objective sleep measures (actigraphy) and clinically relevant endpoints (antibody titers), controlling for major confounders, but lacking randomization.
Source
Sleep and Antibody Response to Hepatitis B Vaccination
Aric A. Prather et al. · SLEEP · 2012
DOI 10.5665/sleep.1990
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →