Hormonal
Overexpression of Atg14 improves hypertriglyceridemia in high-fat diet-treated mice and FoxO-deficient mice by enhancing hepatic autophagy.
This study suggests that boosting liver autophagy genes might help manage high fat levels in the blood, especially when diet or genetics impair normal fat processing. For humans, this underscores the potential value of lifestyle factors that naturally support cellular cleanup processes, such as intermittent fasting or regular exercise.
Conversely, overexpression of Atg14 in both high-fat diet treated wild-type mice and FoxO1/3/4 liver-specific knockout mice improves hypertriglyceridemia.
Why this rating
Strong in vivo evidence showing reversal of pathological states (hypertriglyceridemia) via gene overexpression.
Source
The Autophagy-related Gene 14 (Atg14) Is Regulated by Forkhead Box O Transcription Factors and Circadian Rhythms and Plays a Critical Role in Hepatic Autophagy and Lipid Metabolism
Xiwen Xiong et al. · Journal of Biological Chemistry · 2012
DOI 10.1074/jbc.m112.412569
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