Mixed
Intensive lifestyle modification (ILS) significantly increases the likelihood of regression from pre-diabetes to normal glucose regulation (NGR) compared to placebo, with effects driven by both weight loss and non-weight-loss components of the intervention.
If you have pre-diabetes, you can reverse it. The most effective way is through Intensive Lifestyle Modification (ILS), which involves a low-calorie, low-fat diet and at least 150 minutes of moderate exercise (like brisk walking) per week, aiming for a 7% weight loss. Crucially, even if you don't hit the 7% weight loss goal, the lifestyle changes themselves (diet and exercise) independently help restore normal glucose regulation. Don't rely solely on medication like Metformin for reversal, as it was not significantly effective for this specific outcome in this study. Focus on sustainable habits.
ILS (2.05, P < 0.01) and weight loss (1.34, P < 0.01) had significant and independent effects on regression.
Why this rating
Based on a large, prospective randomized clinical trial (DPP) with rigorous statistical modeling.
Source
Regression From Pre-Diabetes to Normal Glucose Regulation in the Diabetes Prevention Program
Leigh Perreault et al. · Diabetes Care · 2009
DOI 10.2337/dc09-0523
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