Macro partitioning
Animal-based diets high in saturated fats and proteins promote the growth of bile-tolerant and proteolytic bacteria, leading to the production of potentially harmful metabolites like TMAO, ammonia, and hydrogen sulfide, which are linked to inflammation and cardiovascular disease.
If you consume animal products, be aware that high intake of red meat and saturated fats can promote gut bacteria that produce harmful metabolites like TMAO and hydrogen sulfide, linked to heart disease and inflammation. Balance animal proteins with high-fiber plant foods to encourage beneficial SCFA production and mitigate these risks.
An animal-based diet... determines the increase of bile-tolerant microbes such as Alistipes, Bilophila, and Bacteroides... The metabolites such as amines, hydrogen sulfide, p-cresol, and ammonia, are harmful for the colonic epithelium at excessive concentrations... TMAO decreases the transport of reverse cholesterol and bile acid synthesis... explaining the relation between bile acid and TMAO regulation emerging as a possible atherosclerosis mediator
Why this rating
Strong mechanistic evidence from multiple studies cited, linking specific metabolites to disease states.
Source
Gut Microbiota Metabolism and Interaction with Food Components
Pamela Vernocchi et al. · International Journal of Molecular Sciences · 2020
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