Adherence
Gastrointestinal side effects (nausea, vomiting, feeling sick) are the primary drivers of discontinuation for GLP-1 receptor agonists in real-world practice, with patient-reported rates significantly higher than physician perceptions.
If you are taking a GLP-1 medication and stopping because of stomach issues, you are not alone. GI side effects are the most common reason patients quit, often more so than lack of effectiveness. These symptoms are frequently under-recognized by doctors. Talk to your provider about these specific issues; managing expectations and side effects can help you stay on the medication longer.
Physicians (n=443) most frequently reported inadequate blood glucose control (45.6%), nausea/vomiting (43.8%), and gastrointestinal (GI) side effects (36.8%) as reasons for GLP1 RA discontinuation. Patients (n=194) reported the GI-related issues 'Made me feel sick' (64.4%) and 'Made me throw up' (45.4%) as their top reasons for discontinuation.
Why this rating
Cross-sectional survey data from real-world practice; subject to recall bias and self-reporting limitations, but large sample size.
Source
Reasons for discontinuation of GLP1 receptor agonists: data from a real-world cross-sectional survey of physicians and their patients with type 2 diabetes
Mirko Sikirica et al. · Diabetes Metabolic Syndrome and Obesity · 2017
DOI 10.2147/dmso.s141235
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